Simultaneous determination of amiodarone, dronedarone, and their principal metabolites in SD rat plasma by UPLC-MS/MS and its application in pharmacokinetics

Simultaneous determination of amiodarone, dronedarone, and their principal metabolites in SD rat plasma by UPLC-MS/MS and its application in pharmacokinetics

The purpose of the experiment was mainly to establish and verify a precise and straightforward ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) approach for simultaneously analyzing the concentration levels of amiodarone, dronedarone, and their metabolites (desethylamiod...

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Bibliographic Details
Main Authors: Ying Zhang, Mengxiao Zhu, Saili Xie, Xuemei Ye, Xuegu Xu
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Arabian Journal of Chemistry
Subjects:
Amiodarone
Dronedarone
Pharmacokinetics
UPLC-MS/MS
Rat plasma
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535221003154

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http://www.sciencedirect.com/science/article/pii/S1878535221003154

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