Elucidating heavy/light chain pairing preferences to facilitate the assembly of bispecific IgG in single cells

Multiple strategies have been developed to facilitate the efficient production of bispecific IgG (BsIgG) in single host cells. For example, we previously demonstrated near quantitative (≥90%) formation of BsIgG of different species and isotypes by combining ‘knob-into-hole’ mutations for heavy chain...

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Bibliographic Details
Main Authors: Kamal Kishore Joshi, Wilson Phung, Guanghui Han, Yiyuan Yin, Ingrid Kim, Wendy Sandoval, Paul J. Carter
Format: Article
Language:English
Published: Taylor & Francis Group 2019-10-01
Series:mAbs
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2019.1640549