Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

Formation of secondary allo-bile acids by novel enzymes from gut Firmicutes

The gut microbiome of vertebrates is capable of numerous biotransformations of bile acids, which are responsible for intestinal lipid digestion and function as key nutrient-signaling molecules. The human liver produces bile acids from cholesterol predominantly in the A/B-cis orientation in which the...

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Bibliographic Details
Main Authors: Jae Won Lee, Elise S. Cowley, Patricia G. Wolf, Heidi L. Doden, Tsuyoshi Murai, Kelly Yovani Olivos Caicedo, Lindsey K. Ly, Furong Sun, Hajime Takei, Hiroshi Nittono, Steven L. Daniel, Isaac Cann, H. Rex Gaskins, Karthik Anantharaman, João M. P. Alves, Jason M. Ridlon
Format: Article
Language:English
Published: Taylor & Francis Group 2022-12-01
Series:Gut Microbes
Subjects:
Secondary allo-bile acids
bile acid dehydroxylation
bile acid 5α-reductases
Firmicutes
colorectal cancer
Online Access:https://www.tandfonline.com/doi/10.1080/19490976.2022.2132903

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https://www.tandfonline.com/doi/10.1080/19490976.2022.2132903

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