Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production

Nicotinamide-riboside shifts the differentiation of human primary white adipocytes to beige adipocytes impacting substrate preference and uncoupling respiration through SIRT1 activation and mitochondria-derived reactive species production

Beige adipocytes play key roles in organismal energy and metabolic balance. In this study, we assessed whether the supplementation of human white adipocytes, differentiated from human adipose tissue-derived stem cells, with nicotinamide riboside (NR), a potent NAD + precursor, can shift differentiat...

Full description

Bibliographic Details
Main Authors: Lilla Nagy, Boglárka Rauch, Tamás Szerafin, Karen Uray, Attila Tóth, Péter Bai
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
beige adipocyte
mitochondrial oxidation
nicotinamide riboside
uncoupled respiration
adipocyte differentiation
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.979330/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2022.979330/full

Similar Items