Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB

Abstract Accumulating evidence implicates impairment of the autophagy‐lysosome pathway in Alzheimer's disease (AD). Recently discovered, transcription factor EB (TFEB) is a molecule shown to play central roles in cellular degradative processes. Here we investigate the role of TFEB in AD mouse m...

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Bibliographic Details
Main Authors: Vinicia A Polito, Hongmei Li, Heidi Martini‐Stoica, Baiping Wang, Li Yang, Yin Xu, Daniel B Swartzlander, Michela Palmieri, Alberto di Ronza, Virginia M‐Y Lee, Marco Sardiello, Andrea Ballabio, Hui Zheng
Format: Article
Language:English
Published: Springer Nature 2014-07-01
Series:EMBO Molecular Medicine
Subjects:
Alzheimer's disease
tauopathy
TFEB
PTEN
autophagy‐lysosomal pathway
Online Access:https://doi.org/10.15252/emmm.201303671

Internet

https://doi.org/10.15252/emmm.201303671

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