Expanding the Frontier of Linear Drug Design: Cu‐Catalyzed Csp–Csp3‐Coupling of Electron‐Deficient SF4‐Alkynes with Alkyl Iodides

Expanding the Frontier of Linear Drug Design: Cu‐Catalyzed Csp–Csp3‐Coupling of Electron‐Deficient SF4‐Alkynes with Alkyl Iodides

Abstract Despite the attractive properties of tetrafluorosulfanyl (SF4) compounds in drug discovery, medicinal research on SF4 molecules is hindered by the scarcity of suitable synthetic methodologies. Drawing inspiration from the well‐established Sonogashira cross‐coupling of terminal alkynes under...

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Bibliographic Details
Main Authors: Srikanth Reddy Narra, Muhamad Zulfaqar Bacho, Masashi Hattori, Norio Shibata
Format: Article
Language:English
Published: Wiley 2024-03-01
Series:Advanced Science
Subjects:
alkyl iodide
alkyne
cross‐coupling
fluorine
tetrafluorosulfanyl
Online Access:https://doi.org/10.1002/advs.202306554

Internet

https://doi.org/10.1002/advs.202306554

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