Generation of Induced Neuronal Cells by the Single Reprogramming Factor ASCL1

Direct conversion of nonneural cells to functional neurons holds great promise for neurological disease modeling and regenerative medicine. We previously reported rapid reprogramming of mouse embryonic fibroblasts (MEFs) into mature induced neuronal (iN) cells by forced expression of three transcrip...

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Bibliographic Details
Main Authors: Soham Chanda, Cheen Euong Ang, Jonathan Davila, ChangHui Pak, Moritz Mall, Qian Yi Lee, Henrik Ahlenius, Seung Woo Jung, Thomas C. Südhof, Marius Wernig
Format: Article
Language:English
Published: Elsevier 2014-08-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114001878