Dose-Dependent Transcriptional Response to Ionizing Radiation Is Orchestrated with DNA Repair within the Nuclear Space

Dose-Dependent Transcriptional Response to Ionizing Radiation Is Orchestrated with DNA Repair within the Nuclear Space

Radiation therapy is commonly used to treat glioblastoma multiforme (GBM) brain tumors. Ionizing radiation (IR) induces dose-specific variations in transcriptional programs, implicating that they are tightly regulated and critical components in the tumor response and survival. Yet, our understanding...

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Bibliographic Details
Main Authors: Garima Chaturvedi, Avital Sarusi-Portuguez, Olga Loza, Ariel Shimoni-Sebag, Orly Yoron, Yaacov Richard Lawrence, Leor Zach, Ofir Hakim
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:International Journal of Molecular Sciences
Subjects:
GBM
DNA damage response
ionizing radiation
TADs
transcription
genome architecture
Online Access:https://www.mdpi.com/1422-0067/25/2/970

Internet

https://www.mdpi.com/1422-0067/25/2/970

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