11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice

11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice

Abstract Background Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the role of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) in epileptogenesi...

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Bibliographic Details
Main Authors: Xueying Li, Wanhua Qiu, Lu Deng, Jingjing Lin, Wenting Huang, Yuchen Xu, Mulan Zhang, Nigel C. Jones, Runxuan Lin, Huiqin Xu, Li Lin, Peijun Li, Xinshi Wang
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Journal of Translational Medicine
Subjects:
11β-hydroxysteroid dehydrogenase 1 (11β-HSD1)
Epilepsy
Cognitive impairment
Patch clamp
Apoptosis
Online Access:https://doi.org/10.1186/s12967-022-03618-x

Internet

https://doi.org/10.1186/s12967-022-03618-x

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