RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus

RGS14 limits seizure-induced mitochondrial oxidative stress and pathology in hippocampus

RGS14 is a complex multifunctional scaffolding protein that is highly enriched within pyramidal cells (PCs) of hippocampal area CA2. In these neurons, RGS14 suppresses glutamate-induced calcium influx and related G protein and ERK signaling in dendritic spines to restrain postsynaptic signaling and...

Full description

Bibliographic Details
Main Authors: N.H. Harbin, D.J. Lustberg, C. Hurst, J. Pare, K.M. Crotty, A.L. Waters, S.M. Yeligar, Y. Smith, N.T. Seyfried, D. Weinshenker, J.R. Hepler
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Neurobiology of Disease
Subjects:
RGS14
RGS
Hippocampus
CA2
Kainic acid
Seizure
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996123001420

Internet

http://www.sciencedirect.com/science/article/pii/S0969996123001420

Similar Items