Pulmonary hypertension associated with diazoxide: the SUR1 paradox
The ATP-sensitive potassium channels and their regulatory subunits, sulfonylurea receptor 1 (SUR1/Kir6.2) and SUR2/Kir6.1, contribute to the pathophysiology of pulmonary hypertension (PH). Loss-of-function pathogenic variants in the ABCC8 gene, which encodes for SUR1, have been associated with herit...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2023-11-01
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| Series: | ERJ Open Research |
| Online Access: | http://openres.ersjournals.com/content/9/6/00350-2023.full |