Restored autophagy is protective against PAK3-induced cardiac dysfunction

Restored autophagy is protective against PAK3-induced cardiac dysfunction

Summary: Despite the development of clinical treatments, heart failure remains the leading cause of mortality. We observed that p21-activated kinase 3 (PAK3) was augmented in failing human and mouse hearts. Furthermore, mice with cardiac-specific PAK3 overexpression exhibited exacerbated pathologica...

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Bibliographic Details
Main Authors: Andrea Ruiz-Velasco, Rida Raja, Xinyi Chen, Haresh Ganenthiran, Namrita Kaur, Nasser hawimel o Alatawi, Jessica M. Miller, Riham R.E. Abouleisa, Qinghui Ou, Xiangjun Zhao, Oveena Fonseka, Xin Wang, Susanne S. Hille, Norbert Frey, Tao Wang, Tamer M.A. Mohamed, Oliver J. Müller, Elizabeth J. Cartwright, Wei Liu
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular biology
Cell biology
Omics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223010477

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http://www.sciencedirect.com/science/article/pii/S2589004223010477

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