The RESP AI model accelerates the identification of tight-binding antibodies

High-affinity antibodies are often identified through directed evolution but deep leaning methods hold great promise. Here the authors report RESP, a pipeline for efficient identification of high affinity antibodies, and apply this to the PD-L1 antibody Atezolizumab.

Bibliographic Details
Main Authors: Jonathan Parkinson, Ryan Hard, Wei Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-36028-8