A Novel Calcium-Dependent Protein Kinase 1 Inhibitor Potently Prevents <i>Toxoplasma gondii</i> Transmission to Foetuses in Mouse

A Novel Calcium-Dependent Protein Kinase 1 Inhibitor Potently Prevents <i>Toxoplasma gondii</i> Transmission to Foetuses in Mouse

Treatments currently used to prevent congenital toxoplasmosis are non-specific of <i>Toxoplasma gondii</i> and have grievous side effects. To develop a more specific and less toxic drug, we have designed SP230, an imidazo[1,2-<i>b</i>]pyridazine salt targeting the <i>To...

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Bibliographic Details
Main Authors: Héloïse Débare, Nathalie Moiré, Firmin Baron, Louis Lantier, Bruno Héraut, Nathalie Van Langendonck, Caroline Denevault-Sabourin, Isabelle Dimier-Poisson, Françoise Debierre-Grockiego
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Molecules
Subjects:
<i>Toxoplasma gondii</i>
congenital toxoplasmosis
treatment
imidazoazines
Online Access:https://www.mdpi.com/1420-3049/26/14/4203

Internet

https://www.mdpi.com/1420-3049/26/14/4203

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