No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos.

No evidence for AID/MBD4-coupled DNA demethylation in zebrafish embryos.

The mechanisms responsible for active DNA demethylation remain elusive in Metazoa. A previous study that utilized zebrafish embryos provided a potent mechanism for active demethylation in which three proteins, AID, MBD4, and GADD45 are involved. We recently found age-dependent DNA hypomethylation in...

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Bibliografiske detaljer
Main Authors: Nobuyoshi Shimoda, Kentaro Hirose, Reiya Kaneto, Toshiaki Izawa, Hayato Yokoi, Naohiro Hashimoto, Yutaka Kikuchi
Format: Article
Sprog:English
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4275248?pdf=render

Internet

http://europepmc.org/articles/PMC4275248?pdf=render

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