ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity

Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.

Bibliographic Details
Main Authors: Bing Zhu, LuLin Jiang, Timothy Huang, Yingjun Zhao, Tongfei Liu, Yongwang Zhong, Xiaoguang Li, Alexandre Campos, Kenneth Pomeroy, Eliezer Masliah, Dongxian Zhang, Huaxi Xu
Format: Article
Language:English
Published: Nature Portfolio 2017-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-01799-4

Internet

https://doi.org/10.1038/s41467-017-01799-4

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