ER-associated degradation regulates Alzheimer’s amyloid pathology and memory function by modulating γ-secretase activity
Endoplasmic-reticulum associated degradation (ERAD) regulates protein homeostasis. Here the authors identify an ERAD component membralin, and show that it interacts with a member of the γ-secretase complex to regulate β-amyloid (Aβ) pathology and memory deficits in an Alzheimer’s disease model.
Bibliographic Details
| Main Authors: |
Bing Zhu,
LuLin Jiang,
Timothy Huang,
Yingjun Zhao,
Tongfei Liu,
Yongwang Zhong,
Xiaoguang Li,
Alexandre Campos,
Kenneth Pomeroy,
Eliezer Masliah,
Dongxian Zhang,
Huaxi Xu |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2017-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-017-01799-4
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