MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model

MicroRNA Let-7f-5p Promotes Bone Marrow Mesenchymal Stem Cells Survival by Targeting Caspase-3 in Alzheimer Disease Model

Widespread death of transplanted mesenchymal stem cells (MSCs) hampers the development of stem cell therapy for Alzheimer disease (AD). Cell pre-conditioning might help cope with this challenge. We tested whether let-7f-5p-modified MSCs could prolong the survival of MSCs after transplantation. When...

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Bibliographic Details
Main Authors: Linlin Han, Yan Zhou, Ruiyi Zhang, Kaimin Wu, Yanhui Lu, Yanfei Li, Ranran Duan, Yaobing Yao, Dengna Zhu, Yanjie Jia
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-05-01
Series:Frontiers in Neuroscience
Subjects:
Alzheimer disease
cell transplantation
let-7f
bone marrow mesenchymal stem cells
cell apoptosis
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2018.00333/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2018.00333/full

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