Effect of hydroalcoholic seed extract of Nigella sativa on hepatic and pancreatic factors of Nrf2 and FGF21 in the regulation of insulin transcription factors of MafA and PDX-1 in streptozotocin-treated diabetic rats

Effect of hydroalcoholic seed extract of Nigella sativa on hepatic and pancreatic factors of Nrf2 and FGF21 in the regulation of insulin transcription factors of MafA and PDX-1 in streptozotocin-treated diabetic rats

Abstract Introduction Nigella sativa (N. sativa), one of the most commonly used medicinal herbs with antioxidant properties, increases blood insulin levels and lowers fasting blood sugar. Nuclear Erythroid Factor-Related Factor 2 (Nrf2) and Fibroblast Growth Factor 21 (FGF21) are two antioxidant fac...

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Bibliographic Details
Main Authors: Mahsa Soleimani-Dodran, Reza Alipanah-Moghadam, Farhad Jeddi, Mohammad Babaei, Ramin Salimnejad, Elham Bahreini
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Nutrition & Metabolism
Subjects:
Diabetic
Insulin
Nigella sativa
FGF21
NRF2
PDX1
Online Access:https://doi.org/10.1186/s12986-022-00699-9

Internet

https://doi.org/10.1186/s12986-022-00699-9

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