ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1

The authors showed that, in C. elegans, inhibition of translation or mTORC1 increases ATF-4 expression independently of ISR signalling. ATF-4 promotes longevity by increasing hydrogen sulfide production by the enzyme CTH-2.

Bibliographic Details
Main Authors: Cyril Statzer, Jin Meng, Richard Venz, Monet Bland, Stacey Robida-Stubbs, Krina Patel, Dunja Petrovic, Raffaella Emsley, Pengpeng Liu, Ianessa Morantte, Cole Haynes, William B. Mair, Alban Longchamp, Milos R. Filipovic, T. Keith Blackwell, Collin Y. Ewald
Format: Article
Language:English
Published: Nature Portfolio 2022-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-28599-9

Internet

https://doi.org/10.1038/s41467-022-28599-9

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