A pH-sensitive motif in an outer membrane protein activates bacterial membrane vesicle production

Abstract Outer membrane vesicles (OMVs) produced by Gram-negative bacteria have key roles in cell envelope homeostasis, secretion, interbacterial communication, and pathogenesis. The facultative intracellular pathogen Salmonella Typhimurium increases OMV production inside the acidic vacuoles of host...

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Bibliographic Details
Main Authors: Ruchika Dehinwal, Tata Gopinath, Richard D. Smith, Robert K. Ernst, Dieter M. Schifferli, Matthew K. Waldor, Francesca M. Marassi
Format: Article
Language:English
Published: Nature Portfolio 2024-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-51364-z