Comparative Evaluation of the Cytotoxicity of Doxorubicin in BT-20 Triple-Negative Breast Carcinoma Monolayer and Spheroid Cultures

Comparative Evaluation of the Cytotoxicity of Doxorubicin in BT-20 Triple-Negative Breast Carcinoma Monolayer and Spheroid Cultures

Three-dimensional cell culture models are increasingly adopted as preferred pre-clinical drug testing platforms, as they circumvent limitations associated with traditional monolayer cell cultures. However, many of these models are not fully characterized. This study aimed to characterize a BT-20 tri...

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Bibliographic Details
Main Authors: Keith N. Ncube, Tamarin Jurgens, Vanessa Steenkamp, Allan D. Cromarty, Iman van den Bout, Werner Cordier
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Biomedicines
Subjects:
two-dimensional culture model
three-dimensional culture model
BT-20 cells
doxorubicin
drug susceptibility
multicellular spheroids
Online Access:https://www.mdpi.com/2227-9059/11/5/1484

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https://www.mdpi.com/2227-9059/11/5/1484

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