The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses

Recent genome-wide association studies (GWASs) of COVID-19 patients of European ancestry have identified genetic loci significantly associated with disease severity. Here, we employed the detailed clinical, immunological and multi-omics dataset of the Human Functional Genomics Project (HFGP) to expl...

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Bibliographic Details
Main Authors: Yunus Kuijpers, Xiaojing Chu, Martin Jaeger, Simone J. C. F. M. Moorlag, Valerie A. C. M. Koeken, Bowen Zhang, Aline de Nooijer, Inge Grondman, Manoj Kumar Gupta, Nico Janssen, Vera P. Mourits, L. Charlotte J. de Bree, Quirijn de Mast, Frank L. van de Veerdonk, Leo A. B. Joosten, Yang Li, Mihai G. Netea, Cheng-Jian Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
genome-wide association studies
COVID-19
genotyping
cytokine
single-cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.859387/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.859387/full

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