Voriconazole Pharmacokinetics Are Not Altered in Critically Ill Patients with Acute-on-Chronic Liver Failure and Continuous Renal Replacement Therapy: An Observational Study

Voriconazole Pharmacokinetics Are Not Altered in Critically Ill Patients with Acute-on-Chronic Liver Failure and Continuous Renal Replacement Therapy: An Observational Study

Infection and sepsis are a main cause of acute-on-chronic liver failure (ACLF). Besides bacteria, molds play a role. Voriconazole (VRC) is recommended but its pharmacokinetics (PK) may be altered by ACLF. Because ACLF patients often suffer from concomitant acute renal failure, we studied the PK of V...

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Bibliographic Details
Main Authors: Jörn Grensemann, Christoph Pfaffendorf, Sebastian G. Wicha, Christina König, Kevin Roedl, Dominik Jarczak, Stefanie Iwersen-Bergmann, Carolin Manthey, Stefan Kluge, Valentin Fuhrmann
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:Microorganisms
Subjects:
antifungal therapy
target attainment
intensive care
volume of distribution
Monte-Carlo simulation
population pharmacokinetics
Online Access:https://www.mdpi.com/2076-2607/9/10/2087

Internet

https://www.mdpi.com/2076-2607/9/10/2087

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