Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades

Neem Leaf Glycoprotein Restrains VEGF Production by Direct Modulation of HIF1α-Linked Upstream and Downstream Cascades

Neem Leaf Glycoprotein (NLGP) is a natural immunomodulator, have shown sustained tumor growth restriction as well as angiogenic normalization chiefly by activating CD8+ T cells. Here, we have investigated the direct role of NLGP as a regulator of tumor microenvironmental hypoxia and associated vascu...

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Bibliographic Details
Main Authors: Akata Saha, Partha Nandi, Shayani Dasgupta, Avishek Bhuniya, Nilanjan Ganguly, Tithi Ghosh, Ipsita Guha, Saptak Banerjee, Rathindranath Baral, Anamika Bose
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Oncology
Subjects:
hypoxia
VEGF
HIF1α
STAT3
tumor-microenvironment
NLGP
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00260/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00260/full

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