MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing.

MIWI N-terminal RG motif promotes efficient pachytene piRNA production and spermatogenesis independent of LINE1 transposon silencing.

PIWI proteins and their associated piRNAs act to silence transposons and promote gametogenesis. Murine PIWI proteins MIWI, MILI, and MIWI2 have multiple arginine and glycine (RG)-rich motifs at their N-terminal domains. Despite being known as docking sites for the TDRD family proteins, the in vivo r...

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Bibliographic Details
Main Authors: Chao Wei, Jiongjie Jing, Xiaoyuan Yan, Jeffrey M Mann, Ruirong Geng, Huirong Xie, Elena Y Demireva, Rex A Hess, Deqiang Ding, Chen Chen
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-11-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011031&type=printable

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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1011031&type=printable

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