Synthetic route optimization of Sumepirin antiepileptic drug candidate
In this work we describe the transformation of synthetic route of the antiepileptic drug candidate Sumepirin starting from discovery stage. Initial method included six step process requiring two steps of purification using colon chromatography and has poor overall yield of target compound. The proce...
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| Format: | Article |
| Language: | English |
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Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina
2020-12-01
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| Series: | Chimica Techno Acta |
| Subjects: | |
| Online Access: | https://journals.urfu.ru/index.php/chimtech/article/view/4802 |
| _version_ | 1818732481490190336 |
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| author | M. S. Dzyurkevich N. V. Shtyrlin Y. G. Shtyrlin |
| author_facet | M. S. Dzyurkevich N. V. Shtyrlin Y. G. Shtyrlin |
| author_sort | M. S. Dzyurkevich |
| collection | DOAJ |
| description | In this work we describe the transformation of synthetic route of the antiepileptic drug candidate Sumepirin starting from discovery stage. Initial method included six step process requiring two steps of purification using colon chromatography and has poor overall yield of target compound. The process developed is convenient, scalable, technological and meet the most of conditions of green chemistry. The overall yield was increased up to 62.5% in four steps without colon chromatography purification which allows to obtain the target compound with purity of 99.5+% which is especially important for the active ingredient. |
| first_indexed | 2024-12-17T23:34:15Z |
| format | Article |
| id | doaj.art-0b4d80d52c6f45078fe7ada733d90e04 |
| institution | Directory Open Access Journal |
| issn | 2411-1414 |
| language | English |
| last_indexed | 2024-12-17T23:34:15Z |
| publishDate | 2020-12-01 |
| publisher | Uralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. Elʹcina |
| record_format | Article |
| series | Chimica Techno Acta |
| spelling | doaj.art-0b4d80d52c6f45078fe7ada733d90e042022-12-21T21:28:35ZengUralʹskij federalʹnyj universitet imeni pervogo Prezidenta Rossii B.N. ElʹcinaChimica Techno Acta2411-14142020-12-017415916810.15826/chimtech.2020.7.4.043705Synthetic route optimization of Sumepirin antiepileptic drug candidateM. S. Dzyurkevich0N. V. Shtyrlin1Y. G. Shtyrlin2Kazan (Volga region) Federal University, KazanKazan (Volga region) Federal University, KazanKazan (Volga region) Federal University, KazanIn this work we describe the transformation of synthetic route of the antiepileptic drug candidate Sumepirin starting from discovery stage. Initial method included six step process requiring two steps of purification using colon chromatography and has poor overall yield of target compound. The process developed is convenient, scalable, technological and meet the most of conditions of green chemistry. The overall yield was increased up to 62.5% in four steps without colon chromatography purification which allows to obtain the target compound with purity of 99.5+% which is especially important for the active ingredient.https://journals.urfu.ru/index.php/chimtech/article/view/4802pyridoxinesynthetic route optimizationscale-uppurificationantiepileptic drugtechnology |
| spellingShingle | M. S. Dzyurkevich N. V. Shtyrlin Y. G. Shtyrlin Synthetic route optimization of Sumepirin antiepileptic drug candidate Chimica Techno Acta pyridoxine synthetic route optimization scale-up purification antiepileptic drug technology |
| title | Synthetic route optimization of Sumepirin antiepileptic drug candidate |
| title_full | Synthetic route optimization of Sumepirin antiepileptic drug candidate |
| title_fullStr | Synthetic route optimization of Sumepirin antiepileptic drug candidate |
| title_full_unstemmed | Synthetic route optimization of Sumepirin antiepileptic drug candidate |
| title_short | Synthetic route optimization of Sumepirin antiepileptic drug candidate |
| title_sort | synthetic route optimization of sumepirin antiepileptic drug candidate |
| topic | pyridoxine synthetic route optimization scale-up purification antiepileptic drug technology |
| url | https://journals.urfu.ru/index.php/chimtech/article/view/4802 |
| work_keys_str_mv | AT msdzyurkevich syntheticrouteoptimizationofsumepirinantiepilepticdrugcandidate AT nvshtyrlin syntheticrouteoptimizationofsumepirinantiepilepticdrugcandidate AT ygshtyrlin syntheticrouteoptimizationofsumepirinantiepilepticdrugcandidate |