Whole mitogenome sequencing uncovers a relation between mitochondrial heteroplasmy and leprosy severity

Whole mitogenome sequencing uncovers a relation between mitochondrial heteroplasmy and leprosy severity

Abstract Background In recent years, the mitochondria/immune system interaction has been proposed, so that variants of mitochondrial genome and levels of heteroplasmy might deregulate important metabolic processes in fighting infections, such as leprosy. Methods We sequenced the whole mitochondrial...

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Bibliographic Details
Main Authors: Felipe Gouvea de Souza, Moisés Batista da Silva, Gilderlanio S. de Araújo, Caio S. Silva, Andrey Henrique Gama Pinheiro, Miguel Ángel Cáceres-Durán, Mayara Natália Santana-da-Silva, Pablo Pinto, Angélica Rita Gobbo, Patrícia Fagundes da Costa, Claudio Guedes Salgado, Ândrea Ribeiro-dos-Santos, Giovanna C. Cavalcante
Format: Article
Language:English
Published: BMC 2023-12-01
Series:Human Genomics
Subjects:
Leprosy
mtDNA
Haplogroups
Mycobacterium leprae
Mitogenome
Online Access:https://doi.org/10.1186/s40246-023-00555-8

Internet

https://doi.org/10.1186/s40246-023-00555-8

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