Renal functional, transcriptome, and methylome adaptations in pregnant Sprague Dawley and Brown Norway rats

Pregnancy induces maternal renal adaptations that include increased glomerular filtration rate and renal blood flow which can be compromised in obstetrical complications such as preeclampsia. Brown Norway (BN) rat pregnancies are characterized by placental insufficiency, maternal hypertension, and p...

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Bibliographic Details
Main Authors: Zhong Chen, Charles Wang, Arlin Blood, Shannon Bragg, Eugenia Mata-Greenwood
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9202892/?tool=EBI