Nutrient-Driven O-GlcNAcylation at Promoters Impacts Genome-Wide RNA Pol II Distribution

Nutrient-Driven O-GlcNAcylation at Promoters Impacts Genome-Wide RNA Pol II Distribution

Nutrient-driven O-GlcNAcylation has been linked to epigenetic regulation of gene expression in metazoans. In C. elegans, O-GlcNAc marks the promoters of over 800 developmental, metabolic, and stress-related genes; these O-GlcNAc marked genes show a strong 5′, promoter-proximal bias in the distributi...

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Bibliographic Details
Main Authors: Michael W. Krause, Dona C. Love, Salil K. Ghosh, Peng Wang, Sijung Yun, Tetsunari Fukushige, John A. Hanover
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-09-01
Series:Frontiers in Endocrinology
Subjects:
O-GlcNAc
RNA-polymerase II
CTD
transcription
genetic
nutrients
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00521/full

Internet

https://www.frontiersin.org/article/10.3389/fendo.2018.00521/full

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