Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

Role of Glycogen Synthase Kinase-3β in APP Hyperphosphorylation Induced by NMDA Stimulation in Cortical Neurons

The phosphorylation of Amyloid Precursor Protein (APP) at Thr668 plays a key role in APP metabolism that is highly relevant to AD. The c-Jun-N-terminal kinase (JNK), glycogen synthase kinase-3β (GSK-3β) and cyclin-dependent kinase 5 (Cdk5) can all be responsible for this phosphorylation. These kinas...

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Bibliographic Details
Main Authors: Xanthi Antoniou, Gianluigi Forloni, Monica Di Luca, Fabrizio Gardoni, Mariaelena Repici, Alessio Colombo, Alessandra Sclip, Cristina Ploia, Tiziana Borsello
Format: Article
Language:English
Published: MDPI AG 2010-01-01
Series:Pharmaceuticals
Subjects:
APP
NMDA
GSK-3β
JNK
Cdk5
Online Access:http://www.mdpi.com/1424-8247/3/1/42/

Internet

http://www.mdpi.com/1424-8247/3/1/42/

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