Systematical detection of significant genes in microarray data by incorporating gene interaction relationship in biological systems.

Many methods, including parametric, nonparametric, and Bayesian methods, have been used for detecting differentially expressed genes based on the assumption that biological systems are linear, which ignores the nonlinear characteristics of most biological systems. More importantly, those methods do...

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Bibliographic Details
Main Authors: Junwei Wang, Meiwen Jia, Liping Zhu, Zengjin Yuan, Peng Li, Chang Chang, Jian Luo, Mingyao Liu, Tieliu Shi
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2966410?pdf=render