<i>In Silico</i> Analyses, Experimental Verification and Application in DNA Vaccines of Ebolavirus GP-Derived pan-MHC-II-Restricted Epitopes

<i>In Silico</i> Analyses, Experimental Verification and Application in DNA Vaccines of Ebolavirus GP-Derived pan-MHC-II-Restricted Epitopes

(1) Background and Purpose: Ebola virus (EBOV) is the causative agent of Ebola virus disease (EVD), which causes extremely high mortality and widespread epidemics. The only glycoprotein (GP) on the surface of EBOV particles is the key to mediating viral invasion into host cells. DNA vaccines for EBO...

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Bibliographic Details
Main Authors: Junqi Zhang, Baozeng Sun, Wenyang Shen, Zhenjie Wang, Yang Liu, Yubo Sun, Jiaxing Zhang, Ruibo Liu, Yongkai Wang, Tianyuan Bai, Zilu Ma, Cheng Luo, Xupeng Qiao, Xiyang Zhang, Shuya Yang, Yuanjie Sun, Dongbo Jiang, Kun Yang
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:Vaccines
Subjects:
Ebola virus glycoprotein (EBOV GP)
pan-MHC-II epitope
immunoreactivity
in silico analysis
DNA vaccine
enzyme-linked immunospot (ELISpot) assay
Online Access:https://www.mdpi.com/2076-393X/11/10/1620

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https://www.mdpi.com/2076-393X/11/10/1620

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