Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic

Hepatotoxicity prevention in Acetaminophen-induced HepG2 cells by red betel (Piper crocatum Ruiz and Pav) extract from Indonesia via antioxidant, anti-inflammatory, and anti-necrotic

Acetaminophen (APAP) is a widely used analgesic, but it may cause liver injury (hepatotoxicity) via oxidative stress that induced by N-acetyl-p-benzoquinone imine (NAPQI) in long term usage or overdose. Multiple inflammatory mediators were also found to contribute for this effect. Many medicinal pla...

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Bibliographic Details
Main Authors: Chrismis Novalinda Ginting, I Nyoman Ehrich Lister, Ermi Girsang, Wahyu Widowati, Dewani Tediana Yusepany, Alya Mardhotillah Azizah, Hanna Sari Widya Kusuma
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Heliyon
Subjects:
Red betel leaves extract
Acetaminophen
HepG2 cells
Hepatoprotective
Biochemistry
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844020324634

Internet

http://www.sciencedirect.com/science/article/pii/S2405844020324634

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