Intracerebroventricular Administration of Human Umbilical Cord Blood—Derived Mesenchymal Stem Cells Induces Transient Inflammation in a Transgenic Mouse Model and Patients with Alzheimer’s Disease

Intracerebroventricular Administration of Human Umbilical Cord Blood—Derived Mesenchymal Stem Cells Induces Transient Inflammation in a Transgenic Mouse Model and Patients with Alzheimer’s Disease

Previously we conducted a Phase I/IIa clinical trial in nine patients with mild to moderate Alzheimer’s disease (AD). Unexpectedly, all patients who were given injections of human-umbilical cord-blood-derived mesenchymal stem cells (hUCB-MSCs) developed fever which subsided after 24 h. Several possi...

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Bibliographic Details
Main Authors: Su Hyeon Myeong, Hyeongseop Kim, Na Kyung Lee, Jung Won Hwang, Hee Jin Kim, Hyemin Jang, Soo Jin Choi, Duk L. Na
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:Biomedicines
Subjects:
human-umbilical-cord-blood mesenchymal stem cells
intracerebroventricular administration
Alzheimer’s disease
inflammatory responses
fever
Online Access:https://www.mdpi.com/2227-9059/10/3/563

Internet

https://www.mdpi.com/2227-9059/10/3/563

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