Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice

Functional comparison of phosphomimetic S15D and T160D mutants of myosin regulatory light chain exchanged in cardiac muscle preparations of HCM and WT mice

In this study, we investigated the rescue potential of two phosphomimetic mutants of the myosin regulatory light chain (RLC, MYL2 gene), S15D, and T160D RLCs. S15D-RLC mimics phosphorylation of the established serine-15 site of the human cardiac RLC. T160D-RLC mimics the phosphorylation of threonine...

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Bibliographic Details
Main Authors: Katarzyna Kazmierczak, Jingsheng Liang, Michelle Gomez-Guevara, Danuta Szczesna-Cordary
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
myosin RLC
phosphorylation
phosphomimetic S15D and T160D RLCs
reconstituted cardiac muscle preparations
super-relaxed state of myosin
transgenic mice
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.988066/full

Internet

https://www.frontiersin.org/articles/10.3389/fcvm.2022.988066/full

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