Combined HIF-1α and SHH Up-Regulation Is a Potential Biomarker to Predict Poor Prognosis in Postoperative Hepatocellular Carcinoma

Combined HIF-1α and SHH Up-Regulation Is a Potential Biomarker to Predict Poor Prognosis in Postoperative Hepatocellular Carcinoma

Background Hypoxia-inducible factor-1α (HIF-1α) or sonic hedgehog (SHH) is associated with hepatocellular carcinoma (HCC) progression. Hypoxia inhibits ferroptosis, which induces cancer cell death. However, the correlation between the combined HIF-1α and SHH up-regulation with prognosis, and the ass...

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Bibliographic Details
Main Authors: Jiali Zhao, Guifang Zeng, En Lin, Chaonong Cai, Peiping Li, Baojia Zou, Jian Li
Format: Article
Language:English
Published: Taylor & Francis Group 2022-07-01
Series:Journal of Investigative Surgery
Subjects:
hcc
hif-1α
shh
prognosis
ferroptosis
postoperative
Online Access:http://dx.doi.org/10.1080/08941939.2022.2090034

Internet

http://dx.doi.org/10.1080/08941939.2022.2090034

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