Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival

Retrotransposons are usually dormant in healthy tissue, but become activated during malignancy. Here, in colorectal cancer, Cajuso et al. show that retrotransposon activity associates with clinical features of the disease.

Bibliographic Details
Main Authors: Tatiana Cajuso, Päivi Sulo, Tomas Tanskanen, Riku Katainen, Aurora Taira, Ulrika A. Hänninen, Johanna Kondelin, Linda Forsström, Niko Välimäki, Mervi Aavikko, Eevi Kaasinen, Ari Ristimäki, Selja Koskensalo, Anna Lepistö, Laura Renkonen-Sinisalo, Toni Seppälä, Teijo Kuopio, Jan Böhm, Jukka-Pekka Mecklin, Outi Kilpivaara, Esa Pitkänen, Kimmo Palin, Lauri A. Aaltonen
Format: Article
Language:English
Published: Nature Portfolio 2019-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-11770-0

Internet

https://doi.org/10.1038/s41467-019-11770-0

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