Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Complement C5a induces the generation of neutrophil extracellular traps by inhibiting mitochondrial STAT3 to promote the development of arterial thrombosis

Abstract Background Thrombotic events cannot be completely prevented by antithrombotics, implicating a therapeutic gap due to inflammation, a not yet sufficiently addressed mechanism. Neutrophil extracellular traps (NETs) are an essential interface between inflammation and thrombosis, but exactly ho...

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Bibliographic Details
Main Authors: Yejia Chen, Xiaobo Li, Xinxin Lin, Hongbin Liang, Xuewei Liu, Xinlu Zhang, Qiuxia Zhang, Fengyun Zhou, Chen Yu, Li Lei, Jiancheng Xiu
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Thrombosis Journal
Subjects:
Arterial thrombosis
Complement C5a
Neutrophil extracellular traps
Mitochondrial ROS
Mitochondrial STAT3
Online Access:https://doi.org/10.1186/s12959-022-00384-0

Internet

https://doi.org/10.1186/s12959-022-00384-0

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