Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

Evaluation of Xa inhibitors as potential inhibitors of the SARS-CoV-2 Mpro protease.

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Based on previous large-scale in silico screening several factor Xa inhibitors were proposed to potentially inhibit SARS-CoV-2 Mpro. In addition to their known anticoagulants activity this potential inhibition could have an additional therapeutic effect on patients with COVID-19 disease. In this stu...

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Bibliographic Details
Main Authors: Katarzyna Papaj, Patrycja Spychalska, Patryk Kapica, André Fischer, Jakub Nowak, Maria Bzówka, Manuel Sellner, Markus A Lill, Martin Smieško, Artur Góra
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0262482

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https://doi.org/10.1371/journal.pone.0262482

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