mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome. Here the authors implicate the mechanistic target of rapamycin complex 1 in murine models of Still’s disease and macrophage activation sy...

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Bibliographic Details
Main Authors: Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-34480-6

Internet

https://doi.org/10.1038/s41467-022-34480-6

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