A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes

Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based routes of fighting infections problematic. The pH-d...

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Bibliographic Details
Main Authors: Lorena Zuzic, Jan K Marzinek, Ganesh S Anand, Jim Warwicker, Peter J Bond
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-05-01
Series:eLife
Subjects:
flavivirus
enveloped virus
benzene-mapping
cryptic pockets
constant-pH simulations
molecular dynamics simulations
Online Access:https://elifesciences.org/articles/82447

Internet

https://elifesciences.org/articles/82447

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