A pH-dependent cluster of charges in a conserved cryptic pocket on flaviviral envelopes
Flaviviruses are enveloped viruses which include human pathogens that are predominantly transmitted by mosquitoes and ticks. Some, such as dengue virus, exhibit the phenomenon of antibody-dependent enhancement (ADE) of disease, making vaccine-based routes of fighting infections problematic. The pH-d...
Main Authors: | Lorena Zuzic, Jan K Marzinek, Ganesh S Anand, Jim Warwicker, Peter J Bond |
---|---|
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2023-05-01
|
Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/82447 |
Similar Items
-
Drug specificity and affinity are encoded in the probability of cryptic pocket opening in myosin motor domains
by: Artur Meller, et al.
Published: (2023-01-01) -
New treatment strategies for dengue and other flaviviral diseases
Published: (2006) -
Revealing druggable cryptic pockets in the Nsp1 of SARS-CoV-2 and other β-coronaviruses by simulations and crystallography
by: Alberto Borsatto, et al.
Published: (2022-11-01) -
Identification of active pocket and protein druggability within envelope glycoprotein GP2 from Ebola virus
by: Beuy Joob, et al.
Published: (2014-12-01) -
What Features of Ligands Are Relevant to the Opening of Cryptic Pockets in Drug Targets?
by: Zhonghua Xia, et al.
Published: (2022-01-01)