Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals—The Case of Simvastatin

Importance of Mesoporous Silica Particle Size in the Stabilization of Amorphous Pharmaceuticals—The Case of Simvastatin

In this paper, the role of mesoporous silica (MS) particle size in the stabilization of amorphous simvastatin (SVT) is revealed. For inhibiting recrystallization of the supercooled drug, the two MS materials (Syloid<sup>®</sup> XDP 3050 and Syloid<sup>®</sup> 244 FP) were emp...

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Bibliographic Details
Main Authors: Justyna Knapik-Kowalczuk, Daniel Kramarczyk, Krzysztof Chmiel, Jana Romanova, Kohsaku Kawakami, Marian Paluch
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Pharmaceutics
Subjects:
simvastatin
amorphous pharmaceuticals
mesoporous silica
stabilization
recrystallization
Online Access:https://www.mdpi.com/1999-4923/12/4/384

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https://www.mdpi.com/1999-4923/12/4/384

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