Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis

Hepatitis B virus suppresses complement C9 synthesis by limiting the availability of transcription factor USF-1 and inhibits formation of membrane attack complex: implications in disease pathogenesis

Abstract Background The complement system functions primarily as a first-line host defense against invading microbes, including viruses. However, the interaction of Hepatitis B virus (HBV) with the complement-components during chronic HBV infection remains largely unknown. We investigated the mechan...

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Bibliographic Details
Main Authors: Ayana Baidya, Mousumi Khatun, Rajiv Kumar Mondal, Suchandrima Ghosh, Bidhan Chandra Chakraborty, Shreya Mallik, S. K. Mahiuddin Ahammed, Abhijit Chowdhury, Soma Banerjee, Simanti Datta
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Journal of Biomedical Science
Subjects:
Complement C9
HBX
USF-1
Promoter hypermethylation
Membrane attack complex
Online Access:https://doi.org/10.1186/s12929-022-00876-1

Internet

https://doi.org/10.1186/s12929-022-00876-1

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