Light-mediated double-strand DNA cleavage by an alkyldicobalamin

Agents that cause double-strand breaks (DSBs) of DNA via radical formation have been demonstrated to be effective in treating cancer because DSBs result in cellular apoptosis. Light-responsive agents for the treatment of cancer have been of interest for decades because they afford the ability to spa...

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Bibliographic Details
Main Authors: Liberty N. Gendron, Jennifer R. Shell, Thomas A. Shell
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Journal of Photochemistry and Photobiology
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2666469023000507