Light-mediated double-strand DNA cleavage by an alkyldicobalamin
Agents that cause double-strand breaks (DSBs) of DNA via radical formation have been demonstrated to be effective in treating cancer because DSBs result in cellular apoptosis. Light-responsive agents for the treatment of cancer have been of interest for decades because they afford the ability to spa...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | Journal of Photochemistry and Photobiology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666469023000507 |
| _version_ | 1797405349883412480 |
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| author | Liberty N. Gendron Jennifer R. Shell Thomas A. Shell |
| author_facet | Liberty N. Gendron Jennifer R. Shell Thomas A. Shell |
| author_sort | Liberty N. Gendron |
| collection | DOAJ |
| description | Agents that cause double-strand breaks (DSBs) of DNA via radical formation have been demonstrated to be effective in treating cancer because DSBs result in cellular apoptosis. Light-responsive agents for the treatment of cancer have been of interest for decades because they afford the ability to spatially control chemical reactions limiting the effects by controlling the area of illumination. Alkylcobalamins, which are structurally related to Vitamin B12 (B12), produce radicals with very high quantum yields when illuminated with green light (approximately 530 nm). Cancerous cells uptake alkylcobalamins to a greater extent than healthy cells because these rapidly dividing cells have an increased demand for B12. Tethering two cobalamins with a propyl group results in a complex that causes true DNA DSBs in a light-mediated manner. |
| first_indexed | 2024-03-09T03:08:39Z |
| format | Article |
| id | doaj.art-0b7096922d46409a8ff8f68234eccf56 |
| institution | Directory Open Access Journal |
| issn | 2666-4690 |
| language | English |
| last_indexed | 2024-03-09T03:08:39Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Photochemistry and Photobiology |
| spelling | doaj.art-0b7096922d46409a8ff8f68234eccf562023-12-04T05:24:14ZengElsevierJournal of Photochemistry and Photobiology2666-46902023-12-0118100209Light-mediated double-strand DNA cleavage by an alkyldicobalaminLiberty N. Gendron0Jennifer R. Shell1Thomas A. Shell2Department of Chemistry, Saint Anselm College, 100 Saint Anselm Drive, Manchester, NH, 03102, United States; Thayer School of Engineering, Dartmouth College, Hanover, NH 37599, United StatesThayer School of Engineering, Dartmouth College, Hanover, NH 37599, United States; Eos Pharmaceuticals, LLC, 203 Cosby Circle, Tazewell, TN 37879, United StatesDepartment of Chemistry and Physics, Lincoln Memorial University, 6965 Cumberland Gap Parkway, Harrogate, Tennessee, 37752, United States; Corresponding author.Agents that cause double-strand breaks (DSBs) of DNA via radical formation have been demonstrated to be effective in treating cancer because DSBs result in cellular apoptosis. Light-responsive agents for the treatment of cancer have been of interest for decades because they afford the ability to spatially control chemical reactions limiting the effects by controlling the area of illumination. Alkylcobalamins, which are structurally related to Vitamin B12 (B12), produce radicals with very high quantum yields when illuminated with green light (approximately 530 nm). Cancerous cells uptake alkylcobalamins to a greater extent than healthy cells because these rapidly dividing cells have an increased demand for B12. Tethering two cobalamins with a propyl group results in a complex that causes true DNA DSBs in a light-mediated manner.http://www.sciencedirect.com/science/article/pii/S2666469023000507DNA cleavageLight-activatedVitamin B12AlkylcobalaminDouble-strand DNA breaks |
| spellingShingle | Liberty N. Gendron Jennifer R. Shell Thomas A. Shell Light-mediated double-strand DNA cleavage by an alkyldicobalamin Journal of Photochemistry and Photobiology DNA cleavage Light-activated Vitamin B12 Alkylcobalamin Double-strand DNA breaks |
| title | Light-mediated double-strand DNA cleavage by an alkyldicobalamin |
| title_full | Light-mediated double-strand DNA cleavage by an alkyldicobalamin |
| title_fullStr | Light-mediated double-strand DNA cleavage by an alkyldicobalamin |
| title_full_unstemmed | Light-mediated double-strand DNA cleavage by an alkyldicobalamin |
| title_short | Light-mediated double-strand DNA cleavage by an alkyldicobalamin |
| title_sort | light mediated double strand dna cleavage by an alkyldicobalamin |
| topic | DNA cleavage Light-activated Vitamin B12 Alkylcobalamin Double-strand DNA breaks |
| url | http://www.sciencedirect.com/science/article/pii/S2666469023000507 |
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