Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction

Discoidin Domain Receptor 1 Mediates Myosin-Dependent Collagen Contraction

Discoidin domain receptor 1 (DDR1) is a tyrosine kinase collagen adhesion receptor that mediates cell migration through association with non-muscle myosin IIA (NMIIA). Because DDR1 is implicated in cancer fibrosis, we hypothesized that DDR1 interacts with NMIIA to enable collagen compaction by tract...

Full description

Bibliographic Details
Main Authors: Nuno M. Coelho, Pamma D. Arora, Sander van Putten, Stellar Boo, Petar Petrovic, Alyna Xue Lin, Boris Hinz, Christopher A. McCulloch
Format: Article
Language:English
Published: Elsevier 2017-02-01
Series:Cell Reports
Subjects:
DDR1
myosin
collagen remodeling
contraction
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717301183

Internet

http://www.sciencedirect.com/science/article/pii/S2211124717301183

Similar Items