Efficient Synthesis of Key Chiral Intermediate in Painkillers (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine by Bienzyme Cascade System with R-ω-Transaminase and Alcohol Dehydrogenase Functions

Efficient Synthesis of Key Chiral Intermediate in Painkillers (R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanamine by Bienzyme Cascade System with R-ω-Transaminase and Alcohol Dehydrogenase Functions

(R)-1-[3,5-bis(trifluoromethyl)phenyl]ethanamine, a key chiral intermediate of selective tetrodotoxin-sensitive blockers, was efficiently synthesized by a bienzyme cascade system formed by with R-ω-transaminase (ATA117) and an alcohol dehydrogenase (ADH) co-expression system. Herein, we report that...

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Bibliographic Details
Main Authors: Yuan Lu, Jinmei Wang, Haobo Xu, Chuyue Zhang, Pengpeng Cheng, Lihua Du, Lan Tang, Jinghua Li, Zhimin Ou
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:Molecules
Subjects:
alcohol dehydrogenase
bienzyme cascade system
chiral amines
R-ω-transaminase
recombinant engineered bacteria
Online Access:https://www.mdpi.com/1420-3049/27/21/7331

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https://www.mdpi.com/1420-3049/27/21/7331

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