Hydrogen peroxide sensing, signaling and regulation of transcription factors

Hydrogen peroxide sensing, signaling and regulation of transcription factors

The regulatory mechanisms by which hydrogen peroxide (H2O2) modulates the activity of transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and Msn2/4) and mammalian cells (AP-1, NRF2, CREB, HSF1, HIF-1, TP53, NF-κB, NOTCH, SP1 and SCREB-1) are reviewed. The complexit...

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Bibliographic Details
Main Authors: H. Susana Marinho, Carla Real, Luísa Cyrne, Helena Soares, Fernando Antunes
Format: Article
Language:English
Published: Elsevier 2014-01-01
Series:Redox Biology
Subjects:
Redox signaling
Localized H2O2 concentrations
Rate constants
Thiol reactivity
Cytosol-nuclear traffic
DNA binding and transactivation
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231714000457

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http://www.sciencedirect.com/science/article/pii/S2213231714000457

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